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Patient-derived malignant pleural mesothelioma cell cultures: a tool to advance biomarker-driven treatments

Abstract:

Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM. Patient-derived MPM cell cultures (n=16) exhibited stemness features and reflected intratumour and interpatient heterogeneity. A subset of the cells were subjected to high-throughput drug screening and coculture assays with cancer-specific cytotoxic T cells and showed diverse responses. Some of the bipha...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/thoraxjnl-2020-215027

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Role:
Author
ORCID:
0000-0002-0065-2282
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John Fell Fund More from this funder
Publisher:
BMJ Publishing Group Publisher's website
Journal:
Thorax Journal website
Volume:
75
Issue:
11
Pages:
1004-1008
Publication date:
2020-09-17
Acceptance date:
2020-07-14
DOI:
EISSN:
1468-3296
ISSN:
0040-6376
Pmid:
32943495
Language:
English
Keywords:
Pubs id:
1133591
Local pid:
pubs:1133591
Deposit date:
2020-10-05

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