Journal article
Patient-derived malignant pleural mesothelioma cell cultures: a tool to advance biomarker-driven treatments
- Abstract:
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Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM. Patient-derived MPM cell cultures (n=16) exhibited stemness features and reflected intratumour and interpatient heterogeneity. A subset of the cells were subjected to high-throughput drug screening and coculture assays with cancer-specific cytotoxic T cells and showed diverse responses. Some of the bipha...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, 1.3MB)
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- Publisher copy:
- 10.1136/thoraxjnl-2020-215027
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Authors
Funding
John Fell Fund
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Bibliographic Details
- Publisher:
- BMJ Publishing Group Publisher's website
- Journal:
- Thorax Journal website
- Volume:
- 75
- Issue:
- 11
- Pages:
- 1004-1008
- Publication date:
- 2020-09-17
- Acceptance date:
- 2020-07-14
- DOI:
- EISSN:
-
1468-3296
- ISSN:
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0040-6376
- Pmid:
-
32943495
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1133591
- Local pid:
- pubs:1133591
- Deposit date:
- 2020-10-05
Terms of use
- Copyright holder:
- Kanellakis et al.
- Copyright date:
- 2020
- Rights statement:
- ©2020 Author(s) (or their employer(s)). Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
- Notes:
- This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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