ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair

Wells, D; Bitoun, E; Moralli, D; Zhang, G; Hinch, A; Jankowska, J; Donnelly, P; Green, C; Myers, SM

Journal article

ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair

Abstract:: During meiosis, homologous chromosomes pair and recombine, enabling balanced segregation and generating genetic diversity. In many vertebrates, double-strand breaks (DSBs) initiate recombination within hotspots where PRDM9 binds, and deposits H3K4me3 and H3K36me3. However, no protein(s) recognising this unique combination of histone marks have been identified. We identified Zcwpw1, containing H3K4me3 and H3K36me3 recognition domains, as hav...
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Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Wells, D., Bitoun, E., Moralli, D., Zhang, G., Hinch, A., Jankowska, J., Donnelly, P., Green, C., & Myers, S. M. (2020). ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair. Genetics and Genomics, 9(2020).

MLA Style

Wells, D., et al. “ZCWPW1 Is Recruited to Recombination Hotspots by PRDM9, and Is Essential for Meiotic Double Strand Break Repair.” Genetics and Genomics, vol. 9, no. 2020, eLife Sciences Publications, Ltd, 2020.

Chicago Style

Wells, D, E Bitoun, D Moralli, G Zhang, A Hinch, J Jankowska, P Donnelly, C Green, and SM Myers. 2020. “ZCWPW1 Is Recruited to Recombination Hotspots by PRDM9, and Is Essential for Meiotic Double Strand Break Repair.” Genetics and Genomics 9 (2020).
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Files:: WellsetalVoR2020.pdf

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Publisher copy:: 10.7554/elife.53392

Authors

+ Wells, D More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Role:

Author

+ Bitoun, E More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Oxford college:

Magdalen College

Role:

Author

+ Moralli, D More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Role:

Author

+ Zhang, G More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Role:

Author

+ Hinch, A More by this author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

Human Genetics Wt Centre

Role:

Author

More authors...

Bibliographic Details

Publisher:: eLife Sciences Publications, Ltd Publisher's website
Journal:: Genetics and Genomics Journal website
Volume:: 9
Issue:: 2020
Article number:: e53392
Publication date:: 2020-08-03
Acceptance date:: 2020-07-31
DOI:: 10.7554/elife.53392
EISSN:: 2050-084X

Item Description

Language:: English
Pubs id:: 1123617
Local pid:: pubs:1123617
Deposit date:: 2020-08-05

Terms of use

Copyright holder:: Wells et al.
Rights statement:: © 2020, Wells et al. This article is distributed under the terms of the Creative Commons Attribution License permitting unrestricted use and redistribution provided that the original author and source are credited.

Licence:: CC Attribution (CC BY)

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Journal article

ZCWPW1 is recruited to recombination hotspots by PRDM9, and is essential for meiotic double strand break repair

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