Journal article
Quantifying individual noxious-evoked baseline sensitivity to optimise analgesic trials in neonates
- Abstract:
-
Despite the high burden of pain experienced by hospitalised neonates, there are few analgesics with proven efficacy. Testing analgesics in neonates is experimentally and ethically challenging and minimising the number of neonates required to demonstrate efficacy is essential. EEG (electroencephalography)-derived measures of noxious-evoked brain activity can be used to assess analgesic efficacy; however, as variability exists in neonate’s responses to painful procedures, large sample sizes are...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Wellcome Trust
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Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 10
- Article number:
- e65266
- Publication date:
- 2021-04-13
- Acceptance date:
- 2021-03-17
- DOI:
- EISSN:
-
2050-084X
- Pmid:
-
33847561
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1171611
- Local pid:
- pubs:1171611
- Deposit date:
- 2021-05-05
Terms of use
- Copyright holder:
- MM Cobo et al.
- Copyright date:
- 2021
- Rights statement:
- Copyright Cobo et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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