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Characterization of the putative operon containing arylamine N−acetyltransferase (nat) in Mycobacterium bovis BCG

Abstract:

Mycobacterium bovis BCG and Mycobacterium tuberculosis possess a single arylamine N-acetyltransferase whose gene is predicted to occur within a six-gene operon. Deletion of the nat gene caused an extended lag phase in M. bovis BCG and a cell morphology associated with an altered pattern of cell wall mycolates. Analysis of cDNA from M. bovis BCG shows that during in vitro growth all the genes in the putative nat operon are expressed and the open reading frames are contiguous, supporting the ex...

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Journal:
Molecular Microbiology
Volume:
59
Issue:
1
Pages:
181-192
Publication date:
2006-01-01
DOI:
URN:
uuid:142f54ba-b0ad-4ae4-aa10-1965f3548cb2
Local pid:
cs:1442

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