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Molecular evolution of DNMT1 in vertebrates: Duplications in marsupials followed by positive selection

Abstract:

DNA methylation is mediated by a conserved family of DNA methyltransferases (Dnmts). The human genome encodes three active Dnmts (Dnmt1, Dnmt3a and Dnmt3b), the tRNA methyltransferase Dnmt2, and the regulatory protein Dnmt3L. Despite their high degree of conservation among different species, genes encoding Dnmts have been duplicated and/or lost in multiple lineages throughout evolution, indicating that the DNA methylation machinery has some potential to undergo evolutionary change. However, l...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0195162

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Role:
Author
ORCID:
0000-0002-8729-1036
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
Ministry of Economy and Competitiveness of Spain More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
13
Issue:
4
Pages:
e0195162
Publication date:
2018-04-05
Acceptance date:
2018-03-16
DOI:
EISSN:
1932-6203
Pubs id:
pubs:836286
URN:
uri:14287bfe-e32a-4d2b-8f7b-8555a0b1a0af
UUID:
uuid:14287bfe-e32a-4d2b-8f7b-8555a0b1a0af
Local pid:
pubs:836286
Language:
English
Keywords:

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