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An improved formulation of chloroquine for intramuscular administration: absorption kinetics in rabbits.

Abstract:

Intramuscular chloroquine is rapidly absorbed, even in severe falciparum malaria, and may cause potentially lethal hypotension. Less rapidly absorbed formulations should be safer. A chloroquine phosphate solution containing 2% methylcellulose 1500 released chloroquine 2.6 times more slowly than a commercial aqueous solution in an in-vitro absorption simulator. There was a log linear relationship between viscosity and release rate. The absorption pharmacokinetics of the more viscous chloroquin...

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Publication status:
Published

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Authors


Prakongpan, S More by this author
Sirimai, S More by this author
Edwards, G More by this author
McGrath, CS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Journal:
The Journal of pharmacy and pharmacology
Volume:
41
Issue:
10
Pages:
726-728
Publication date:
1989-10-05
DOI:
EISSN:
2042-7158
ISSN:
0022-3573
URN:
uuid:1424494b-2149-4a86-8c75-5a0eadae2f84
Source identifiers:
43138
Local pid:
pubs:43138

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