Altered CD45 expression and disease.

Journal article

Abstract:: CD45, the leucocyte common antigen, is a haemopoietic cell-specific tyrosine phosphatase. Many isoforms are generated by alternative splicing, but their function remains obscure. The extracellular domain of CD45 is highly polymorphic in all vertebrates. Importantly, human polymorphic variants that alter CD45 isoform expression are associated with autoimmune and infectious diseases, establishing CD45 as an important immunomodulator with a significant influence on disease burden. Here, we discu...
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Role:

Author

Institution:

University of Oxford

Division:

MSD

Department:

NDM

Sub department:

NDM Experimental Medicine

Role:

Author

Language:: English
Keywords:: Genetic Variation

Humans

Polymorphism, Genetic

Alleles

Exons

Gene Expression

Antigens, CD45

Genetic Diseases, Inborn

Animals
Pubs id:: pubs:33362
UUID:: uuid:14000baa-a8f4-4de0-9c52-1fe19364c100
Local pid:: pubs:33362
Source identifiers:: 33362
Deposit date:: 2012-12-19

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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