Journal article icon

Journal article

Drug development for the treatment of onchocerciasis: population pharmacokinetic and adverse events modeling of emodepside

Abstract:

Background
To accelerate the progress towards onchocerciasis elimination, a macrofilaricidal drug that kills the adult parasite is urgently needed. Emodepside has shown macrofilaricidal activity against a variety of nematodes and is currently under clinical development for the treatment of onchocerciasis. The aims of this study were i) to characterize the population pharmacokinetic properties of emodepside, ii) to link its exposure to adverse events in healthy voluntee...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pntd.0010219

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-1146-3452
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0002-5322-912X
More by this author
Role:
Author
ORCID:
0000-0003-4242-9289
More from this funder
Name:
Bill and Melinda Gates Foundation
Publisher:
Public Library of Science
Journal:
PLoS Neglected Tropical Diseases More from this journal
Volume:
16
Issue:
3
Article number:
e0010219
Publication date:
2022-03-10
Acceptance date:
2022-02-01
DOI:
EISSN:
1935-2735
ISSN:
1935-2727
Pmid:
35271567
Language:
English
Keywords:
Pubs id:
1243691
Local pid:
pubs:1243691
Deposit date:
2023-01-10

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP