Greater endothelial activation, Weibel-Palade body release and host inflammatory response to Plasmodium vivax, compared with Plasmodium falciparum: a prospective study in Papua, Indonesia.

Journal article

Pathogenic mechanisms underlying vivax malaria are poorly understood, with few studies comparing endothelial and inflammatory responses with falciparum malaria. In adults with uncomplicated vivax or falciparum malaria, we compared plasma measurements of endothelial Weibel-Palade body release (angiopoietin-2) and activation (ICAM-1, E-selectin), as well as selected cytokines. Despite a lower median parasite count, angiopoietin-2 concentrations were higher in patients with vivax malaria, compar...

Expand abstract

Authors: Yeo, T; Lampah, D; Tjitra, E; Piera, K; Gitawati, R

• Publication status: Published
• Journal: Journal of infectious diseases
• Volume: 202
• Issue: 1
• Pages: 109-112
• Publication date: 2010-07-01
• DOI: 10.1086/653211
• EISSN: 1537-6613
• ISSN: 0022-1899
• Language: English
• Keywords: Plasmodium vivax; E-Selectin; Intercellular Adhesion Molecule-1; Gene Expression Regulation; Interleukin-10; Animals; Inflammation; Weibel-Palade Bodies; Interleukin-6; Humans; Malaria, Vivax; Malaria, Falciparum; Plasmodium falciparum; Indonesia