CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection.

Journal article

CD8(+) cytotoxic T lymphocytes (CTL) play a key role in the control of many virus infections, and the need for vaccines to elicit strong CD8(+) T-cell responses in order to provide optimal protection in such infections is increasingly apparent. However, the mechanisms involved in the induction and maintenance of CD8(+) CTL memory are currently poorly understood. In this study, we investigated the involvement of CD40 ligand (CD40L)-mediated interactions in these processes by analyzing the memo...

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Authors: Borrow, P; Tough, D; Eto, D; Tishon, A; Grewal, I

• Publication status: Published
• Journal: Journal of virology
• Volume: 72
• Issue: 9
• Pages: 7440-7449
• Publication date: 1998-09-01
• EISSN: 1098-5514
• ISSN: 0022-538X
• Language: English
• Keywords: Immunologic Memory; T-Lymphocytes, Cytotoxic; Mice, Inbred C57BL; CD40 Ligand; Hematopoietic Stem Cells; Lymphocytic choriomeningitis virus; Membrane Glycoproteins; Mice; H-Y Antigen; Animals; CD4-Positive T-Lymphocytes