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Journal article

Molecular cross-talk between the transcription, translation, and nonsense-mediated decay machineries.

Abstract:

It is widely believed that translation occurs only in the cytoplasm of eukaryotes, but recent results suggest some takes place in nuclei, coupled to transcription. Support for this heterodoxy comes from studies of the nonsense-mediated decay (NMD) pathway; this pathway probably uses ribosomes to proofread messenger RNAs. We find components of the machineries involved in transcription, translation and NMD colocalise, interact and copurify, and that interactions between them are probably mediat...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.00933

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Journal of cell science
Volume:
117
Issue:
Pt 6
Pages:
899-906
Publication date:
2004-02-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:139c6436-5d70-4649-9131-4017f70444b9
Source identifiers:
12646
Local pid:
pubs:12646

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