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Drosophila PLP assembles pericentriolar clouds that promote centriole stability, cohesion and MT nucleation

Abstract:

Pericentrin is a conserved centrosomal protein whose dysfunction has been linked to several human diseases. It has been implicated in many aspects of centrosome and cilia function, but its precise role is unclear. Here, we examine Drosophila Pericentrin-like-protein (PLP) function in vivo in tissues that form both centrosomes and cilia. Plp mutant centrioles exhibit four major defects: (1) They are short and have subtle structural abnormalities; (2) They disengage prematurely, and so overdupl...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1371/journal.pgen.1007198

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pathology Dunn School
Oxford college:
Lincoln College
Role:
Author
ORCID:
0000-0002-4689-1297
More from this funder
Funding agency for:
Roque, H
More from this funder
Funding agency for:
Raff, J
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
14
Issue:
2
Pages:
Article: e1007198
Publication date:
2018-02-09
Acceptance date:
2018-01-12
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Pubs id:
pubs:935468
URN:
uri:139a3719-0f33-49e5-9cc1-817f45ac0a4b
UUID:
uuid:139a3719-0f33-49e5-9cc1-817f45ac0a4b
Local pid:
pubs:935468
Keywords:

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