Journal article
Drosophila PLP assembles pericentriolar clouds that promote centriole stability, cohesion and MT nucleation
- Abstract:
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Pericentrin is a conserved centrosomal protein whose dysfunction has been linked to several human diseases. It has been implicated in many aspects of centrosome and cilia function, but its precise role is unclear. Here, we examine Drosophila Pericentrin-like-protein (PLP) function in vivo in tissues that form both centrosomes and cilia. Plp mutant centrioles exhibit four major defects: (1) They are short and have subtle structural abnormalities; (2) They disengage prematurely, and so overdupl...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 32.2MB)
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- Publisher copy:
- 10.1371/journal.pgen.1007198
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Authors
Funding
+ Biotechnology and Biological Sciences Research Council
More from this funder
Funding agency for:
Pratt, M
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS Genetics Journal website
- Volume:
- 14
- Issue:
- 2
- Article number:
- e1007198
- Publication date:
- 2018-02-09
- Acceptance date:
- 2018-01-12
- DOI:
- EISSN:
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1553-7404
- ISSN:
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1553-7390
- Source identifiers:
-
935468
Item Description
- Keywords:
- Pubs id:
-
pubs:935468
- UUID:
-
uuid:139a3719-0f33-49e5-9cc1-817f45ac0a4b
- Local pid:
- pubs:935468
- Deposit date:
- 2018-11-08
Terms of use
- Copyright holder:
- Roque et al
- Copyright date:
- 2018
- Notes:
- © 2018 Roque et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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