Journal article icon

Journal article

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites.

Abstract:

Bromodomains are readers of the epigenetic code that specifically bind acetyl-lysine containing recognition sites on proteins. Recently the BET family of bromodomains has been demonstrated to be druggable through the discovery of potent inhibitors, sparking an interest in protein-protein interaction inhibitors that directly target gene transcription. Here, we assess the druggability of diverse members of the bromodomain family using SiteMap and show that there are significant differences in p...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/jm300346w

Authors


Vidler, LR More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Hoelder, S More by this author
Journal:
Journal of medicinal chemistry
Volume:
55
Issue:
17
Pages:
7346-7359
Publication date:
2012-09-05
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
URN:
uuid:13890a9e-54d2-4166-9fdc-4938146da846
Source identifiers:
352730
Local pid:
pubs:352730

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP