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Journal article

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites.

Abstract:

Bromodomains are readers of the epigenetic code that specifically bind acetyl-lysine containing recognition sites on proteins. Recently the BET family of bromodomains has been demonstrated to be druggable through the discovery of potent inhibitors, sparking an interest in protein-protein interaction inhibitors that directly target gene transcription. Here, we assess the druggability of diverse members of the bromodomain family using SiteMap and show that there are significant differences in p...

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Publication status:
Published

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Publisher copy:
10.1021/jm300346w

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
Journal:
Journal of medicinal chemistry
Volume:
55
Issue:
17
Pages:
7346-7359
Publication date:
2012-09-01
DOI:
EISSN:
1520-4804
ISSN:
0022-2623
Source identifiers:
352730
Language:
English
Keywords:
Pubs id:
pubs:352730
UUID:
uuid:13890a9e-54d2-4166-9fdc-4938146da846
Local pid:
pubs:352730
Deposit date:
2013-11-16

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