- Abstract:
-
Bromodomains are readers of the epigenetic code that specifically bind acetyl-lysine containing recognition sites on proteins. Recently the BET family of bromodomains has been demonstrated to be druggable through the discovery of potent inhibitors, sparking an interest in protein-protein interaction inhibitors that directly target gene transcription. Here, we assess the druggability of diverse members of the bromodomain family using SiteMap and show that there are significant differences in p...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1021/jm300346w
-
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- Journal:
- Journal of medicinal chemistry
- Volume:
- 55
- Issue:
- 17
- Pages:
- 7346-7359
- Publication date:
- 2012-09-05
- DOI:
- EISSN:
-
1520-4804
- ISSN:
-
0022-2623
- URN:
-
uuid:13890a9e-54d2-4166-9fdc-4938146da846
- Source identifiers:
-
352730
- Local pid:
- pubs:352730
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites.
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