Journal article
TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism
- Abstract:
-
Background Transforming growth factor-β (TGFβ) is emerging as a promising target for cancer therapy, given its ability to promote progression of advanced tumors and to suppress anti-tumor immune responses. However, TGFβ also plays multiple roles in normal tissues, particularly during organogenesis, raising toxicity concerns about TGFβ blockade. Dose-limiting cardiovascular toxicity was observed, possibly due to the blockade of all three TGFβ isoforms. The dominant isoform in tumors is TGFβ1, ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- BMJ Publishing Group Publisher's website
- Journal:
- Journal for ImmunoTherapy of Cancer Journal website
- Volume:
- 9
- Issue:
- 2
- Article number:
- e001798
- Place of publication:
- England
- Publication date:
- 2021-02-26
- Acceptance date:
- 2021-01-06
- DOI:
- ISSN:
-
2051-1426
- Pmid:
-
33637600
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1163936
- Local pid:
- pubs:1163936
- Deposit date:
- 2021-05-18
Terms of use
- Copyright holder:
- Canè et al.
- Copyright date:
- 2021
- Rights statement:
- © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.
- Licence:
- CC Attribution-NonCommercial (CC BY-NC)
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