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Interfacial activation of M37 lipase: a multi-scale simulation study

Abstract:

Lipases are enzymes of biotechnological importance that function at the interface formed between hydrophobic and aqueous environments. Hydrophobic interfaces can induce structural transitions in lipases that result in an increase in enzyme activity, although the detailed mechanism of this process is currently not well understood for many lipases. Here, we present a multi-scale molecular dynamics simulation study of how different interfaces affect the conformational dynamics of the psychrophil...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.bbamem.2016.12.012

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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Department:
Oxford, MSD, Biochemistry
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Department:
Christ Church
Publisher:
Elsevier Publisher's website
Journal:
Biochimica et Biophysica Acta (BBA) - Biomembranes Journal website
Volume:
1859
Issue:
3
Pages:
340-349
Publication date:
2016-12-18
Acceptance date:
2016-12-15
DOI:
ISSN:
0005-2736
Pubs id:
pubs:666049
URN:
uri:133a1e63-b1c9-4ff6-8718-fe9e6a168b95
UUID:
uuid:133a1e63-b1c9-4ff6-8718-fe9e6a168b95
Local pid:
pubs:666049

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