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An evolving story of the metastatic voyage of ovarian cancer cells: Cellular and molecular orchestration of the adipose-rich metastatic microenvironment

Abstract:

Metastasis is a complex multistep process that involves critical interactions between cancer cells and a variety of stromal components in the tumor microenvironment, which profoundly influence the different aspects of the metastatic cascade and organ tropism of disseminating cancer cells. Ovarian cancer is the most lethal gynecological malignancy and is characterized by peritoneal disseminated metastasis. Evidence has demonstrated that ovarian cancer possesses specific metastatic tropism fo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41388-018-0637-x

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Institute of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Women’s & Reproductive Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Institute of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Institute of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Institute of Molecular Medicine
Role:
Author
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Ovarian Cancer Action More from this funder
More from this funder
Grant:
Oxford Biomedical Research Centre
Helen Clarke Fund More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Oncogene Journal website
Volume:
38
Pages:
2885–2898
Publication date:
2018-12-19
Acceptance date:
2018-11-19
DOI:
ISSN:
1476-5594
Pubs id:
pubs:945684
URN:
uri:132f9aae-7c42-4b01-805f-b468fdf0177d
UUID:
uuid:132f9aae-7c42-4b01-805f-b468fdf0177d
Local pid:
pubs:945684

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