Thesis
Understanding the role of Neuregulin 1-erbB signalling in microglia in the context of neuropathic pain.
- Abstract:
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Neuregulin 1 (NRG1) is a growth factor required for peripheral nerve development and functional recovery following nerve injury. However, its importance in regulating neuropathic pain via microglial signaling remains unclear. Previous pharmacological studies suggest NRG1 regulates microglial proliferation, mechanical allodynia and cold hypersensitivity through binding to extracellular tyrosine kinase receptors (e.g. erbB2, erbB3 and erbB4) found on microglia.
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Funding
Wellcome Trust
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:132dd730-69c2-4bf5-8226-eebcb97f4d41
- Deposit date:
- 2016-07-11
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Terms of use
- Copyright holder:
- Sikander, S
- Copyright date:
- 2015
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