Dataset
Lysine Demethylase JMJD2D (KDM4D); A Targeting Enabling Package
- Documentation:
- A description of the materials and methods is included within the TEP datasheet. There are 4 members of the Lysine Demethylase JMJD2 (KDM4) family. SGC Oxford has expressed, purified and crystallized the catalytic domains of JMJD2A, JMJD2B, JMJD2C and JMJD2D as part of the probe programme. Fragment screening and X-ray crystallography identified a large number of binders, some of which were progressed into a medicinal chemistry programme. Despite significant effort molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
- Version:
- 2
Actions
Authors/Creators
Contributors
+ Brennan, P
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Sub department:
- Structural Genomics Consortium
- Role:
- Principal Investigator (PI), Adapter
+ Yapp, C
- Role:
- Researcher
+ Velupillai, S
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Sub department:
- Structural Genomics Consortium
- Role:
- Researcher
+ Fairhead, M
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Sub department:
- Structural Genomics Consortium
- Role:
- Researcher
+ Hatch, S
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- NDM
- Sub department:
- Target Discovery Institute
- Role:
- Researcher
- Publisher:
- University of Oxford
- Publication date:
- 2018
- Version number:
- 2
- Keywords:
- Subjects:
- UUID:
-
uuid:1314f1af-8438-4b6e-87f3-6df1a0616b80
- Deposit date:
-
2018-04-20
Terms of use
- Copyright date:
- 2018
- Notes:
- This deposition represents version 2 of the TEP datasheet. Changes include, but are not limited to: Addition of hyperlinks throughout the body of the datasheet; Addition of Useful Links to relevant databases; Addition of a Reference box where applicable; Other modifications necessary for page spacing and visualisation. Please note, all data and results within the document remain the same as provided in version 1.
- Licence:
- ORA Terms and conditions
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