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Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Abstract:

Loss of first-phase insulin secretion is an early sign of developing type 2 diabetes (T2D). Ca2+ entry through voltage-gated L-type Ca2+ channels triggers exocytosis of insulin-containing granules in pancreatic β cells and is required for the postprandial spike in insulin secretion. Using high-resolution microscopy, we have identified a subset of docked insulin granules in human β cells and rat-derived clonal insulin 1 (INS1) cells for which localized Ca2+ influx triggers exocytosis with high...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1172/jci88491

Authors


Gandasi, NR More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; OCDEM
Cortese, G More by this author
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Funding agency for:
Rorsman, P
Swedish Science Council More from this funder
Diabetes Wellness Network Sweden More from this funder
Swedish Diabetes Society More from this funder
European Foundation for the Study of Diabetes More from this funder
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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
127
Issue:
6
Pages:
2353-2364
Publication date:
2017-05-08
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pubs id:
pubs:694183
URN:
uri:130df3a5-cc04-4d62-81e4-6f3f271f35ba
UUID:
uuid:130df3a5-cc04-4d62-81e4-6f3f271f35ba
Local pid:
pubs:694183
Language:
English

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