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Structures of the archaerhodopsin-3 transporter reveal that disordering of internal water networks underpins receptor sensitization

Abstract:

Many transmembrane receptors have a desensitized state, in which they are unable to respond to external stimuli. The family of microbial rhodopsin proteins includes one such group of receptors, whose inactive or dark-adapted (DA) state is established in the prolonged absence of light. Here, we present high-resolution crystal structures of the ground (light-adapted) and DA states of Archaerhodopsin-3 (AR3), solved to 1.1 Å and 1.3 Å resolution respectively. We obse...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-020-20596-0

Authors


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Role:
Author
ORCID:
0000-0002-1337-6424
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Institution:
University of Oxford
Division:
MSD
Sub department:
Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0003-0609-0900
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Role:
Author
ORCID:
0000-0002-0891-5008
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Role:
Author
ORCID:
0000-0001-7694-8525
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
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Wellcome Trust More from this funder
Publisher:
Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
12
Issue:
1
Article number:
629
Publication date:
2021-01-27
Acceptance date:
2020-12-10
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
33504778

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