Journal article
Secreted proteins defy the expression level–evolutionary rate anticorrelation
- Abstract:
-
The rates of evolution of the proteins of any organism vary across orders of magnitude. A primary factor influencing rates of protein evolution is expression. A strong negative correlation between expression levels and evolutionary rates (the so-called E–R anticorrelation) has been observed in virtually all studied organisms. This effect is currently attributed to the abundance-dependent fitness costs of misfolding and unspecific protein–protein interactions, among other factors. Secreted pro...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Molecular Biology and Evolution Journal website
- Volume:
- 34
- Issue:
- 3
- Pages:
- 692-706
- Publication date:
- 2016-12-26
- Acceptance date:
- 2016-11-15
- DOI:
- EISSN:
-
1537-1719
- ISSN:
-
0737-4038
- Pmid:
-
28007979
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:836292
- UUID:
-
uuid:12f27c2c-52df-45eb-9fa1-fd30e1392433
- Local pid:
- pubs:836292
- Source identifiers:
-
836292
- Deposit date:
- 2018-08-21
Terms of use
- Copyright holder:
- Feyertag et al
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 The Authors. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
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