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Label-free single molecule imaging with numerical aperture-shaped interferometric scattering microscopy

Abstract:

Our ability to optically interrogate nanoscopic objects is controlled by the difference between their extinction cross sections and the diffraction-limited area to which light can be confined in the far-field. Here, we show that a partially transmissive spatial mask placed near the back focal plane of a high numerical aperture microscope objective enhances the extinction contrast of a scatterer near an interface by approximately T^-1/2, where T is the transmissivity of the mask. Numerical ape...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/acsphotonics.6b00912

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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
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Department:
Oxford, MPLS, Chemistry, Physical & Theoretical Chem
More by this author
Department:
Exeter College
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Photonics Journal website
Volume:
4
Issue:
2
Pages:
211-216
Publication date:
2017-01-18
DOI:
EISSN:
2330-4022
Pubs id:
pubs:660240
URN:
uri:12f1b6dd-3de4-47a7-af7b-569a12c674de
UUID:
uuid:12f1b6dd-3de4-47a7-af7b-569a12c674de
Local pid:
pubs:660240

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