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Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo.

Abstract:

Malarial anemia is a global public health problem and is characterized by a low reticulocyte response in the presence of life-threatening hemolysis. Although cytokines, in particular tumor necrosis factor-alpha (TNF-alpha), can suppress erythropoiesis, the grossly abnormal bone marrow morphology indicates that other factors may contribute to ineffective erythropoiesis. We hypothesized that the cytotoxic hemozoin (Hz) residues from digested hemoglobin (Hb) significantly contribute to abnormal ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Cheung, JO More by this author
Williams, S More by this author
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Journal:
Blood
Volume:
108
Issue:
8
Pages:
2569-2577
Publication date:
2006-10-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:12dbd9a8-f3e0-48ca-a921-8b40810a289a
Source identifiers:
33520
Local pid:
pubs:33520

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