- Abstract:
-
Malarial anemia is a global public health problem and is characterized by a low reticulocyte response in the presence of life-threatening hemolysis. Although cytokines, in particular tumor necrosis factor-alpha (TNF-alpha), can suppress erythropoiesis, the grossly abnormal bone marrow morphology indicates that other factors may contribute to ineffective erythropoiesis. We hypothesized that the cytotoxic hemozoin (Hz) residues from digested hemoglobin (Hb) significantly contribute to abnormal ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1182/blood-2006-05-018697
-
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- Journal:
- Blood
- Volume:
- 108
- Issue:
- 8
- Pages:
- 2569-2577
- Publication date:
- 2006-10-05
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- URN:
-
uuid:12dbd9a8-f3e0-48ca-a921-8b40810a289a
- Source identifiers:
-
33520
- Local pid:
- pubs:33520
- Copyright date:
- 2006
Journal article
Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo.
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