- Abstract:
-
Medical countermeasures to treat biothreat agent infections require broad-spectrum therapeutics that do not induce agent resistance. A cell-based high-throughput screen (HTS) against ricin toxin combined with hit optimization allowed selection of a family of compounds that meet these requirements. The hit compound Retro-2 and its derivatives have been demonstrated to be safe in vivo in mice even at high doses. Moreover, Retro-2 is an inhibitor of retrograde transport that affects syntaxin-5- ...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1016/j.cbi.2016.10.005
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Chemico-Biological Interactions Journal website
- Volume:
- 267
- Pages:
- 96-103
- Publication date:
- 2016-10-03
- Acceptance date:
- 2016-10-03
- DOI:
- EISSN:
-
1872-7786
- ISSN:
-
0009-2797
- Pubs id:
-
pubs:856900
- URN:
-
uri:12d971f9-3452-450f-92a4-4b0d64664cbe
- UUID:
-
uuid:12d971f9-3452-450f-92a4-4b0d64664cbe
- Local pid:
- pubs:856900
- Copyright date:
- 2016
Journal article
Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales
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French National Research Council
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LERMIT LabEx
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Ile de France Region
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Swedish Research Council
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French Alternative Energies and Atomic Energy Commission
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