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Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales

Abstract:

Medical countermeasures to treat biothreat agent infections require broad-spectrum therapeutics that do not induce agent resistance. A cell-based high-throughput screen (HTS) against ricin toxin combined with hit optimization allowed selection of a family of compounds that meet these requirements. The hit compound Retro-2 and its derivatives have been demonstrated to be safe in vivo in mice even at high doses. Moreover, Retro-2 is an inhibitor of retrograde transport that affects syntaxin-5- ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.cbi.2016.10.005

Authors


Hinsinger, K More by this author
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French National Research Council More from this funder
LERMIT LabEx More from this funder
Ile de France Region More from this funder
Swedish Research Council More from this funder
French Alternative Energies and Atomic Energy Commission More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Chemico-Biological Interactions Journal website
Volume:
267
Pages:
96-103
Publication date:
2016-10-03
Acceptance date:
2016-10-03
DOI:
EISSN:
1872-7786
ISSN:
0009-2797
Pubs id:
pubs:856900
URN:
uri:12d971f9-3452-450f-92a4-4b0d64664cbe
UUID:
uuid:12d971f9-3452-450f-92a4-4b0d64664cbe
Local pid:
pubs:856900

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