Journal article
A Plasmodium berghei sporozoite-based vaccination platform against human malaria
- Abstract:
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There is a pressing need for safe and highly effective Plasmodium falciparum (Pf) malaria vaccines. The circumsporozoite protein (CS), expressed on sporozoites and during early hepatic stages, is a leading target vaccine candidate, but clinical efficacy has been modest so far. Conversely, whole-sporozoite (WSp) vaccines have consistently shown high levels of sterilizing immunity and constitute a promising approach to effective immunization against malaria. Here, we describe a novel WSp malari...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
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(pdf, 2.2MB)
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- Publisher copy:
- 10.1038/s41541-018-0068-2
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Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature Publisher's website
- Journal:
- npj Vaccines Journal website
- Volume:
- 3
- Pages:
- Article: 33
- Publication date:
- 2018-08-24
- Acceptance date:
- 2018-05-31
- DOI:
- EISSN:
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2059-0105
- Pubs id:
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pubs:911145
- URN:
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uri:12d960b1-b7f6-4f8d-a73a-29b0d4795ae3
- UUID:
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uuid:12d960b1-b7f6-4f8d-a73a-29b0d4795ae3
- Local pid:
- pubs:911145
Terms of use
- Copyright holder:
- Mendes et al.
- Copyright date:
- 2018
- Notes:
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© The Author(s) 2018. This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
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indicated otherwise in a credit line to the material. If material is not included in the
article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly
from the copyright holder. To view a copy of this license, visit http://creativecommons.
org/licenses/by/4.0/
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