- Abstract:
-
There is a pressing need for safe and highly effective Plasmodium falciparum (Pf) malaria vaccines. The circumsporozoite protein (CS), expressed on sporozoites and during early hepatic stages, is a leading target vaccine candidate, but clinical efficacy has been modest so far. Conversely, whole-sporozoite (WSp) vaccines have consistently shown high levels of sterilizing immunity and constitute a promising approach to effective immunization against malaria. Here, we describe a novel WSp malari...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 2.2mb)
-
- Publisher copy:
- 10.1038/s41541-018-0068-2
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- npj Vaccines Journal website
- Volume:
- 3
- Pages:
- Article: 33
- Publication date:
- 2018-08-24
- Acceptance date:
- 2018-05-31
- DOI:
- EISSN:
-
2059-0105
- Pubs id:
-
pubs:911145
- URN:
-
uri:12d960b1-b7f6-4f8d-a73a-29b0d4795ae3
- UUID:
-
uuid:12d960b1-b7f6-4f8d-a73a-29b0d4795ae3
- Local pid:
- pubs:911145
- Copyright holder:
- Mendes et al.
- Copyright date:
- 2018
- Notes:
-
© The Author(s) 2018. This article is licensed under a Creative Commons
Attribution 4.0 International License, which permits use, sharing,
adaptation, distribution and reproduction in any medium or format, as long as you give
appropriate credit to the original author(s) and the source, provide a link to the Creative
Commons license, and indicate if changes were made. The images or other third party
material in this article are included in the article’s Creative Commons license, unless
indicated otherwise in a credit line to the material. If material is not included in the
article’s Creative Commons license and your intended use is not permitted by statutory
regulation or exceeds the permitted use, you will need to obtain permission directly
from the copyright holder. To view a copy of this license, visit http://creativecommons.
org/licenses/by/4.0/
Journal article
A Plasmodium berghei sporozoite-based vaccination platform against human malaria
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