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Epigenetic pathway inhibitors represent potential drugs for treating pancreatic and bronchial neuroendocrine tumors

Abstract:

Cancer is associated with alterations in epigenetic mechanisms such as histone modifications and methylation of DNA, and inhibitors targeting epigenetic mechanisms represent a novel class of anti-cancer drugs. Neuroendocrine tumors (NETs) of the pancreas (PNETs) and bronchus (BNETs), which may have 5-year survivals of <50% and as low as 5%, respectively, represent targets for such drugs, as >40% of PNETs and ~35% of BNETs have mutations of the multiple endocrine neoplasia type 1 (MEN1) ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/oncsis.2017.30

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Grant:
Oxford Biomedical Research Centre Programme
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Funding agency for:
Lines, K
Grant:
G9825289
G1000462
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Funding agency for:
Stevenson, M
Grant:
G9825289
G1000462
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Funding agency for:
Thakker, R
Grant:
G9825289
G1000462
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Publisher:
Springer Nature Publisher's website
Journal:
Oncogenesis Journal website
Volume:
6
Issue:
5
Article number:
e332
Publication date:
2017-05-15
Acceptance date:
2017-03-28
DOI:
ISSN:
2157-9024
Source identifiers:
695770
Language:
English
Keywords:
Pubs id:
pubs:695770
UUID:
uuid:12c588c4-25ef-48d7-9e37-ab06b829f773
Local pid:
pubs:695770
Deposit date:
2017-05-19

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