Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Journal article

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking statu...

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Authors: Bentley, AR; Sung, YJ; Brown, MR; Goel, A; Morris, AP

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer Nature Publisher's website
• Journal: Nature Genetics Journal website
• Volume: 51
• Issue: 4
• Pages: 636-648
• Publication date: 2019-03-29
• Acceptance date: 2019-02-07
• DOI: 10.1038/s41588-019-0378-y
• EISSN: 1546-1718
• ISSN: 1061-4036
• Pmid: 30926973
• Language: English
• Keywords: Lifelines Cohort; Linkage Disequilibrium; Smoking; Understanding Society Scientific Group; Female; COGENT-Kidney Consortium; Journal Article; Middle Aged; Genotype; Research Support, Non-U.S. Gov't; Aged, 80 and over; Lipids; Meta-Analysis; Young Adult; EPIC-InterAct Consortium; Aged; Humans; Adolescent; Genome-Wide Association Study; Life Style; Adult; Male; Research Support, N.I.H., Extramural