Journal article
Airway epithelial cells generate pro-inflammatory tenascin-C and small extracellular vesicles in response to TLR3 stimuli and rhinovirus infection
- Abstract:
-
Viral infections are a common cause of asthma exacerbations, with human rhinoviruses (RV) the most common trigger. RV signals through a number of different receptors, including toll-like receptor (TLR)3. Tenascin-C (TN-C) is an immunomodulatory extracellular matrix protein present in high quantities in the airway of people with asthma, and expression is also upregulated in nasal lavage fluid in response to RV infection. Respiratory viral infection has been demonstrated to induce the release o...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Frontiers Media Publisher's website
- Journal:
- Frontiers in Immunology
- Volume:
- 10
- Article number:
- 1987
- Publication date:
- 2019-08-21
- Acceptance date:
- 2019-08-06
- DOI:
- EISSN:
-
1664-3224
- Pmid:
-
31497021
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1049124
- UUID:
-
uuid:12afd546-b55f-4102-b089-8b718aeacad5
- Local pid:
- pubs:1049124
- Source identifiers:
-
1049124
- Deposit date:
- 2019-09-30
Terms of use
- Copyright date:
- 2019
- Notes:
- © 2019 Mills, Schwenzer, Marsh, Edwards, Sabroe, Midwood and Parker. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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