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In vivo and in vitro activities and ADME-Tox profile of a quinolizidine-modified 4-aminoquinoline: A potent Anti-P. falciparum and anti-P. vivax blood-stage antimalarial

Abstract:

Natural products are a prolific source for the identification of new biologically active compounds. In the present work, we studied the in vitro and in vivo antimalarial efficacy and ADME-Tox profile of a molecular hybrid (AM1) between 4-aminoquinoline and a quinolizidine moiety derived from lupinine (Lupinus luteus). The aim was to find a compound endowed with the target product profile-1 (TCP-1: molecules that clear asexual blood-stage parasitaemia), proposed by the Medicine for Malaria Ven...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3390/molecules22122102

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Role:
Author
ORCID:
0000-0003-2135-2649
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Role:
Author
ORCID:
0000-0003-4692-7314
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Italian Ministry of Education, Universities and Research More from this funder
European Cooperation in Science and Technology More from this funder
Publisher:
MDPI Publisher's website
Journal:
Molecules Journal website
Volume:
22
Issue:
12
Pages:
2102
Publication date:
2017-12-05
Acceptance date:
2017-11-29
DOI:
EISSN:
1420-3049
ISSN:
1420-3049
Pubs id:
pubs:811142
URN:
uri:12af3bf4-4ed8-48a2-a908-b83f4473dca4
UUID:
uuid:12af3bf4-4ed8-48a2-a908-b83f4473dca4
Local pid:
pubs:811142

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