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Population pharmacokinetics and pharmacodynamics of lumefantrine in young Ugandan children treated with artemether-lumefantrine for uncomplicated malaria

Abstract:

The pharmacokinetics and pharmacodynamics of lumefantrine, a component of the most widely used treatment for malaria, artemether-lumefantrine, has not been adequately characterized in young children.Capillary whole-blood lumefantrine concentration and treatment outcomes were determined in 105 Ugandan children, ages 6 months to 2 years, who were treated for 249 episodes of Plasmodium falciparum malaria with artemether-lumefantrine.Population pharmacokinetics for lumefantrine used a 2-compartme...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jiw338

Authors


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Grant:
clinical scientist development award to S. P. [grant 2007055
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Grant:
throughtheDepartmentofHealth
HumanServices/Centers forDiseaseControl
Prevention(U62P024421
National Center for HIV, Viral Hepatitis, STD, and TB Prevention More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Infectious Diseases Journal website
Volume:
214
Issue:
8
Pages:
1243-1251
Publication date:
2016-10-01
Acceptance date:
2016-07-23
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Pmid:
27471317
Source identifiers:
638619
Language:
English
Keywords:
Pubs id:
pubs:638619
UUID:
uuid:12775a58-bb47-48dc-a7cf-7fd9f1d522f4
Local pid:
pubs:638619
Deposit date:
2016-10-11

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