Journal article
Population pharmacokinetics and pharmacodynamics of lumefantrine in young Ugandan children treated with artemether-lumefantrine for uncomplicated malaria
- Abstract:
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The pharmacokinetics and pharmacodynamics of lumefantrine, a component of the most widely used treatment for malaria, artemether-lumefantrine, has not been adequately characterized in young children.Capillary whole-blood lumefantrine concentration and treatment outcomes were determined in 105 Ugandan children, ages 6 months to 2 years, who were treated for 249 episodes of Plasmodium falciparum malaria with artemether-lumefantrine.Population pharmacokinetics for lumefantrine used a 2-compartme...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 435.1KB)
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- Publisher copy:
- 10.1093/infdis/jiw338
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Authors
Funding
+ Doris Duke Charitable
Foundation
More from this funder
Grant:
clinical scientist development award to S. P. [grant
2007055
+ President′s Emergency Plan for
AIDS Relief
More from this funder
Grant:
throughtheDepartmentofHealth
HumanServices/Centers
forDiseaseControl
Prevention(U62P024421
National Center
for HIV, Viral Hepatitis, STD, and TB Prevention
More from this funder
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Journal of Infectious Diseases Journal website
- Volume:
- 214
- Issue:
- 8
- Pages:
- 1243-1251
- Publication date:
- 2016-10-01
- Acceptance date:
- 2016-07-23
- DOI:
- EISSN:
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1537-6613
- ISSN:
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0022-1899
- Pmid:
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27471317
- Source identifiers:
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638619
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:638619
- UUID:
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uuid:12775a58-bb47-48dc-a7cf-7fd9f1d522f4
- Local pid:
- pubs:638619
- Deposit date:
- 2016-10-11
Terms of use
- Copyright holder:
- Tchaparian et al
- Copyright date:
- 2016
- Notes:
-
Copyright © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited.
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