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Aspirin as adjuvant therapy for colorectal cancer - Reinterpreting paradigms

Abstract:

A high-quality body of evidence supports the use of aspirin in reducing sporadic and hereditary adenomatous polyps, and numerous observational studies point to a reduction in colorectal cancer (CRC) risk. However, using aspirin as an adjuvant therapy in established CRC was until recently inconceivable. Now, evidence from both observational and clinical trials of aspirin for other indications suggests that aspirin initiation after (or before) the diagnosis of CRC improves CRC-specific mortalit...

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Publisher copy:
10.1038/nrclinonc.2012.137

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Institution:
University of Oxford
Department:
Oxford, MSD, Cancer Epidemiology Unit
Journal:
Nature Reviews Clinical Oncology
Volume:
9
Issue:
10
Pages:
561-570
Publication date:
2012-10-01
DOI:
EISSN:
1759-4782
ISSN:
1759-4774
URN:
uuid:1275d344-4c84-4233-8541-f86fcf9002e1
Source identifiers:
354742
Local pid:
pubs:354742

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