Journal article
Modular synthesis of di- and trisubstituted imidazoles from ketones and aldehydes: a route to kinase inhibitors
- Abstract:
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A one-pot and modular approach to the synthesis of 2,4(5)-disubstituted imidazoles was developed based on ketone oxidation, employing catalytic HBr and DMSO, followed by imidazole condensation with aldehydes. This methodology afforded twenty-nine disubstituted NH-imidazoles (23%–85% yield). A three-step synthesis of 20 kinase inhibitors was achieved by employing this oxidation–condensation protocol, followed by bromination and Suzuki coupling in the imidazole ring to yield trisubstituted NH-i...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, 1.4MB, Terms of use)
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- Publisher copy:
- 10.1021/acs.joc.9b01844
Authors
Bibliographic Details
- Publisher:
- American Chemical Society
- Journal:
- Journal of Organic Chemistry More from this journal
- Volume:
- 84
- Issue:
- 21
- Pages:
- 14187-14201
- Publication date:
- 2019-08-28
- Acceptance date:
- 2019-08-28
- DOI:
- EISSN:
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1520-6904
- ISSN:
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0022-3263
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:1059921
- UUID:
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uuid:12648292-ba92-4167-9aae-38a7cce35e42
- Local pid:
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pubs:1059921
- Source identifiers:
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1059921
- Deposit date:
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2019-10-06
Terms of use
- Copyright holder:
- de Toledo, I et al.
- Copyright date:
- 2019
- Rights statement:
- © 2019 de Toledo, I et al. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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