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Investigating the effect of hypoxia on the JmjC histone lysine demethylase KDM4A

Abstract:

The JmjC-histone lysine demethylases (JmjC-KDMs) are epigenetic regulators responsible for the demethylation of methylated lysine residues on the N-terminal histone tails. As Fe2+ and 2-oxoglutarate dependent oxygenases (2OG oxygenases), the JmjC-KDMs possess an absolute requirement for molecular oxygen and are related to the cellular oxygen sensing HIF hydroxylases, PHD2 and FIH. Several JmjC-KDMs are known HIF target genes, hence are upregulated in hypoxia. Moreover, ...

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Division:
MSD
Department:
Chemistry
Department:
University of Oxford
Role:
Author

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Department:
University of Oxford
Role:
Supervisor
Department:
University of Oxford
Role:
Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
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UUID:
uuid:125fb1f5-91be-4902-bb8f-7dd5e089b654
Deposit date:
2018-01-24

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