Journal article icon

Journal article

The allelic landscape of human blood cell trait variation and links to common complex disease

Abstract:

Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a genome-wide association analysis in the UK Biobank and INTERVAL studies, testing 29.5 million genetic variants for association with 36 red cell, white cell, and platelet properties in 173,480 European-ancestry participants. This effort yielded hundreds of low frequency (<5%) and rare (<1%) variants with a strong impact on blood cell ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.cell.2016.10.042

Authors


Expand authors...
Publisher:
Cell Press Publisher's website
Journal:
Cell Journal website
Volume:
167
Issue:
5
Pages:
1415-1429.e19
Publication date:
2016-11-17
Acceptance date:
2016-10-21
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Pubs id:
pubs:663852
URN:
uri:1255007c-8fab-4730-8662-79c7e574a9c4
UUID:
uuid:1255007c-8fab-4730-8662-79c7e574a9c4
Local pid:
pubs:663852
Paper number:
5

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP