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Thesis

Genome engineering and gene drive in the mosquito aedes aegypti

Abstract:

Genetic control strategies are a novel method for reducing populations of pest insects such as the yellow fever mosquito Aedes aegypti, a major vector of several important arboviral diseases. This thesis describes efforts to develop new tools to engineer the Ae. aegypti genome and to better understand existing tools, and furthermore to use these to engineer a gene drive system in Ae. aegypti. The piggyBac transposon was found to be extremely stable in the germline of Ae. aegypti, and trans...

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Role:
Supervisor
Role:
Sponsor
Institution:
University of Oxford
Oxford college:
Linacre College
Department:
Mathematical,Physical & Life Sciences Division - Zoology
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:1251080e-cf7b-4bdd-b01e-d01748ead2d2
Local pid:
ora:6843

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