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Bone Morphogenetic Protein and Notch signaling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer

Abstract:

The functional role of Bone Morphogenetic Protein (BMP) signaling in colorectal cancer (CRC) is poorly defined, with contradictory results in cancer cell line models reflecting the inherent difficulties of assessing a signaling pathway that is context dependent and subject to genetic constraints. By assessing the transcriptional response of a diploid human colonic epithelial cell line to BMP ligand stimulation we generated a prognostic BMP signaling signature, which was applied to multiple...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/path.4891

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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More from this funder
Funding agency for:
Leedham, S
Grant:
MR/K000063/1
More from this funder
Funding agency for:
Leedham, S
Grant:
MR/K000063/1
Publisher:
Wiley Publisher's website
Journal:
Journal of Pathology Journal website
Volume:
242
Issue:
2
Pages:
178-192
Publication date:
2017-05-03
Acceptance date:
2017-02-21
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Source identifiers:
681334
Keywords:
Pubs id:
pubs:681334
UUID:
uuid:12375377-16ef-45d7-bc64-64768fae76d8
Local pid:
pubs:681334
Deposit date:
2017-02-21

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