Journal article
Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein
- Abstract:
-
The retinoblastoma tumour suppressor protein (pRb) classically functions to regulate early cell cycle progression where it acts to enforce a number of checkpoints in response to cellular stress and DNA damage. Methylation at lysine (K) 810, which occurs within a critical CDK phosphorylation site and antagonises a CDK-dependent phosphorylation event at the neighbouring S807 residue, acts to hold pRb in the hypo-phosphorylated growth-suppressing state. This is mediated in part by the recruitmen...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Cell Death and Differentiation More from this journal
- Volume:
- 24
- Pages:
- 139–2149
- Publication date:
- 2017-08-25
- Acceptance date:
- 2017-07-14
- DOI:
- EISSN:
-
1476-5403
- ISSN:
-
1350-9047
- Pmid:
-
28841214
Item Description
- Language:
-
English
- Pubs id:
-
pubs:725920
- UUID:
-
uuid:121bb1f8-cf5c-4800-ab87-5a850fc32244
- Local pid:
-
pubs:725920
- Deposit date:
-
2017-09-14
Terms of use
- Copyright holder:
- Carr et al
- Copyright date:
- 2017
- Notes:
- This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record