Sleep and rest regulation in young and old oestrogen-deficient female mice.

Journal article

The effect of circulating oestrogen deficiency on sleep regulation and locomotor activity was investigated in aromatase cytochrome P450 deficient mice (ArKO) and wild-type (WT) controls. Sleep was recorded in 3-month old mice during a 24-h baseline day, 6-h sleep deprivation (SD) and 18-h recovery, and activity was recorded at the age of 3, 9 and 12 months. In mice deficient of oestrogen, the total amount of sleep per 24 h was the same as in WT controls. However, in ArKO mice, sleep was enhan...

Expand abstract

Authors: Vyazovskiy, V; Kopp, C; Wigger, E; Jones, M; Simpson, E

• Journal: Journal of neuroendocrinology
• Volume: 18
• Issue: 8
• Pages: 567-576
• Publication date: 2006-08-01
• DOI: 10.1111/j.1365-2826.2006.01452.x
• EISSN: 1365-2826
• ISSN: 0953-8194
• Language: English
• Keywords: Electroencephalography; Female; Homeostasis; Circadian Rhythm; Aromatase; Mice, Knockout; Motor Activity; Sleep Stages; Statistics, Nonparametric; Age Factors; Mice; Wakefulness; Mice, Inbred C57BL; Estrogens; Animals