Journal article
Severe infections emerge from commensal bacteria by adaptive evolution
- Abstract:
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Bacteria responsible for the greatest global mortality colonize the human microbiota far more frequently than they cause severe infections. Whether mutation and selection among commensal bacteria are associated with infection is unknown. We investigated de novo mutation in 1163 Staphylococcus aureus genomes from 105 infected patients with nose colonization. We report that 72% of infections emerged from the nose, with infecting and nose-colonizing bacteria showing parallel adaptive differences...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 812.8KB)
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- Publisher copy:
- 10.7554/eLife.30637.001
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Authors
Funding
+ Wellcome Trust
More from this funder
Funding agency for:
Young, BC
Grant:
Research Training Fellow (101611/Z/13/Z
+ Wellcome Trust
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Funding agency for:
Iqbal, Z
Grant:
Sir Henry Dale Fellow 102541/Z/13/Z
+ Royal Society
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Funding agency for:
Iqbal, Z
Grant:
Sir Henry Dale Fellow 102541/Z/13/Z
+ Wellcome Trust
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Funding agency for:
Crook, DW
Grant:
Sir Henry Dale Fellow 101237/Z/13/Z
+ National Institute for Health Research
More from this funder
Funding agency for:
Crook, DW
Grant:
Sir Henry Dale Fellow 101237/Z/13/Z
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Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 6
- Article number:
- e30637
- Publication date:
- 2017-12-19
- Acceptance date:
- 2017-12-02
- DOI:
- ISSN:
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2050-084X
- Source identifiers:
-
808731
Item Description
- Pubs id:
-
pubs:808731
- UUID:
-
uuid:11ce86d6-b2c2-488d-9ff2-d45f1198e0a5
- Local pid:
- pubs:808731
- Deposit date:
- 2017-12-04
Terms of use
- Copyright holder:
- Young et al
- Copyright date:
- 2017
- Notes:
-
Copyright© 2017, Young et al.
This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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