Crystal structures of a rat anti-CD52 (CAMPATH-1) therapeutic antibody Fab fragment and its humanized counterpart.

Journal article

The CAMPATH-1 family of antibodies are able systematically to lyse human lymphocytes with human complement by targeting the small cell-surface glycoprotein CD52, commonly called the CAMPATH-1 antigen. These antibodies have been used clinically for several years, providing therapy for patients with a variety of immunologically mediated diseases. We report here the first X-ray crystallographic analyses of a Fab fragment from a rat antibody, the original therapeutic monoclonal CAMPATH-1G and its...

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Authors: Cheetham, G; Hale, G; Waldmann, H; Bloomer, A

• Publication status: Published
• Journal: Journal of molecular biology
• Volume: 284
• Issue: 1
• Pages: 85-99
• Publication date: 1998-11-01
• DOI: 10.1006/jmbi.1998.2157
• EISSN: 1089-8638
• ISSN: 0022-2836
• Language: English
• Keywords: Antigens, CD; Molecular Sequence Data; Models, Molecular; Antibodies, Monoclonal; Protein Conformation; Humans; Crystallography, X-Ray; Rats; Antibodies, Monoclonal, Humanized; Glycoproteins; Antigens, Neoplasm; Antibodies, Neoplasm; Immunoglobulin Fab Fragments; Animals; Amino Acid Sequence; Binding Sites