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Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease

Abstract:

BACKGROUND: Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes. METHODOLOGY: We applied a recently developed tool for mining GWAS data for biologically meaningful information to a LOAD GWAS dataset. T...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0013950

Authors


Holmans, PA More by this author
Hamshere, ML More by this author
Moskvina, V More by this author
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Alzheimers Research UK More from this funder
Wellcome Trust More from this funder
Medical Research Council More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
5
Issue:
11
Pages:
e13950
Publication date:
2010-11-15
DOI:
EISSN:
1932-6203
Pubs id:
pubs:115980
URN:
uri:1192881f-3060-46ac-9049-45980e894aa7
UUID:
uuid:1192881f-3060-46ac-9049-45980e894aa7
Local pid:
pubs:115980

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