Journal article
A single cycle influenza virus coated in H7 haemagglutinin generates neutralizing antibody responses to haemagglutinin and neuraminidase glycoproteins and protection from heterotypic challenge
- Abstract:
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A non-replicating form of pseudotyped influenza virus, inactivated by suppression of the haemagglutinin signal sequence (S-FLU), can act as a broadly protective vaccine. S-FLU can infect for a single round only, and induces heterotypic protection predominantly through activation of cross-reactive T cells in the lung. Unlike the licensed live attenuated virus, it cannot reassort a pandemic haemagglutinin (HA) into seasonal influenza. Here we present data on four new forms of S-FLU coated with ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, pdf, 148.3KB)
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(Accepted manuscript, pdf, 80.4KB)
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(Accepted manuscript, pdf, 73.1KB)
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(Accepted manuscript, pdf, 74.4KB)
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(Accepted manuscript, pdf, 45.5KB)
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(Accepted manuscript, pdf, 51.8KB)
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(Accepted manuscript, pdf, 343.2KB)
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- Publisher copy:
- 10.1099/jgv.0.001228
Authors
Bibliographic Details
- Publisher:
- Microbiology Society Publisher's website
- Journal:
- Journal of General Virology Journal website
- Volume:
- 100
- Pages:
- 431-445
- Publication date:
- 2019-02-04
- Acceptance date:
- 2019-01-15
- DOI:
- EISSN:
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1465-2099
- ISSN:
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0022-1317
Item Description
- Keywords:
- Pubs id:
-
pubs:960164
- UUID:
-
uuid:117291f7-e7d2-4871-a35f-cc15c87ff7b1
- Local pid:
- pubs:960164
- Source identifiers:
-
960164
- Deposit date:
- 2019-01-16
Terms of use
- Copyright holder:
- Powell et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors. This is the accepted manuscript version of the article. The final version is available online from Microbiology Society at: https://doi.org/10.1099/jgv.0.001228
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