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The tyrosine phosphatase SHP-1 promotes T cell adhesion by activating the adaptor protein CrkII in the immunological synapse

Abstract:

The adaptor protein CrkII is a key regulator of T cell adhesion through the recruitment of the Rap1-guanine exchange factor, C3G. Subsequently, Rap1 activates the integrin LFA-1 leading to T cell adhesion and interaction with antigen presenting cells (APC). The interphase between T cell and APC is known as the immunological synapse (IS). It is characterized by specific organization of proteins that can be divided into central supramolecular activation clusters (c- SMAC) and peripheral supramo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1126/scisignal.aal2880

Authors


Azoulay-Alfaguter, I More by this author
Strazza, M More by this author
More by this author
Department:
Oxford, MSD, NDORMS, KIR
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Irma T. Hirschl Trust More from this funder
Colton Family More from this funder
Rheumatology Research Foundation More from this funder
Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Signaling Journal website
Volume:
10
Issue:
491
Pages:
eaal2880
Publication date:
2017-08-08
Acceptance date:
2017-07-25
DOI:
EISSN:
1945-0877
ISSN:
1937-9145
Pubs id:
pubs:713395
URN:
uri:11592b3b-0978-4832-b897-144beff16eb9
UUID:
uuid:11592b3b-0978-4832-b897-144beff16eb9
Local pid:
pubs:713395
Language:
English
Keywords:

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