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Exploring TLR adaptor protein MyD88 as a sensitivity determinant to HDAC inhibitors

Abstract:

Carcinogenesis has shown to be a result of aberrant genetic as well as epigenetic processes. Histone Deacetylase (HDAC) inhibitors, a class of therapeutic agents developed against the latter, have been shown to be efficient against certain haematological malignancies. However, the underlying molecular mechanisms are still largely unknown. An unbiased loss-of-function screen was used to identify genes that govern cellular sensitivity to HDAC inhibitors (HDIs). Myeloid differentiation primar...

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Department:
Department of Oncology
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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