- Abstract:
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Carcinogenesis has shown to be a result of aberrant genetic as well as epigenetic processes. Histone Deacetylase (HDAC) inhibitors, a class of therapeutic agents developed against the latter, have been shown to be efficient against certain haematological malignancies. However, the underlying molecular mechanisms are still largely unknown. An unbiased loss-of-function screen was used to identify genes that govern cellular sensitivity to HDAC inhibitors (HDIs). Myeloid differentiation primar...
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- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Copyright date:
- 2017
Thesis
Exploring TLR adaptor protein MyD88 as a sensitivity determinant to HDAC inhibitors
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