Thesis
Exploring TLR adaptor protein MyD88 as a sensitivity determinant to HDAC inhibitors
- Abstract:
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Carcinogenesis has shown to be a result of aberrant genetic as well as epigenetic processes. Histone Deacetylase (HDAC) inhibitors, a class of therapeutic agents developed against the latter, have been shown to be efficient against certain haematological malignancies. However, the underlying molecular mechanisms are still largely unknown. An unbiased loss-of-function screen was used to identify genes that govern cellular sensitivity to HDAC inhibitors (HDIs). Myeloid differentiation primar...
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Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- UUID:
-
uuid:1122b3a7-b1fd-4ee1-a9af-ef91b785c1cd
- Deposit date:
- 2019-06-24
Related Items
Terms of use
- Copyright holder:
- Bekheet, M
- Copyright date:
- 2017
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