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Understanding abnormal uterine artery Doppler waveforms: a novel computational model to explore potential causes within the utero-placental vasculature

Abstract:

Introduction: Uterine artery (UtA) Doppler indices are one of the most commonly employed screening tests for pre-eclampsia worldwide. Abnormal indices appear to result from increased uterine vascular resistance, but anatomical complexity and lack of appropriate animal models mean that little is known about the relative contribution of each of the components of the uterine vasculature to the overall UtA Doppler waveform. Previous computational models suggested that trophoblast-mediated spir...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.placenta.2018.05.001

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Obstetrics and Gynaecology
Department:
Oxford, MSD, Womens & Reproductive Health
Role:
Author
ORCID:
0000-0002-0648-7433
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Funding agency for:
Stevenson, G
Collins, S
Grant:
UO1 HD 087209
UO1 HD 087209
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Funding agency for:
Stevenson, G
Collins, S
Grant:
UO1 HD 087209
UO1 HD 087209
More from this funder
Funding agency for:
Clark, A
James, J
Grant:
14-UOA-019
13-UOA-032
Publisher:
Elsevier
Journal:
Placenta More from this journal
Volume:
66
Pages:
74-81
Publication date:
2018-05-09
Acceptance date:
2018-05-02
DOI:
ISSN:
0143-4004 and 1532-3102
Pubs id:
pubs:847407
UUID:
uuid:10d8dc21-eb30-4952-a743-a966fe3660a7
Local pid:
pubs:847407
Source identifiers:
847407
Deposit date:
2018-05-12

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