Journal article
Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis.
- Abstract:
-
PURPOSE: Ras/Raf/mitogen-activated protein-extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling is critical for tumor cell proliferation and survival. Selumetinib is a potent, selective, and orally available MEK1/2 inhibitor. In this study, we evaluated the therapeutic efficacy of selumetinib alone or with cediranib, an orally available potent inhibitor of all three VEGF receptor (VEGFR) tyrosine kinases, in murine orthotopic non-small cell lung carcinoma (NSCLC) models. EXP...
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- Publication status:
- Published
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- Publisher copy:
- 10.1158/1078-0432.ccr-11-2324
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Bibliographic Details
- Journal:
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Volume:
- 18
- Issue:
- 6
- Pages:
- 1641-1654
- Publication date:
- 2012-03-01
- DOI:
- EISSN:
-
1557-3265
- ISSN:
-
1078-0432
- Source identifiers:
-
315410
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:315410
- UUID:
-
uuid:10b68dd8-46bc-40b8-b9dc-dccc9ede10e8
- Local pid:
- pubs:315410
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2012
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