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Journal article

Preformulation studies of ceftriaxone for pediatric non-parenteral administration as an alternative to existing injectable formulations

Abstract:

Ceftriaxone, a third generation cephalosporin, has a wide antibacterial spectrum that has good CNS penetration, which makes it potentially suitable for initial treatment of severe neonatal pediatric infections providing suitable formulation. We evaluated its physicochemical and technical characteristics to assess its potential for development as a non-parenteral dosage form. As ceftriaxone is marked only for injectable use, these data are not available. Using HPLC and Karl Fischer titration, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ejps.2017.04.010

Authors


Marchivie, M More by this author
Phoeung, T More by this author
Gaubert, A More by this author
Désiré, A More by this author
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Publisher:
Elsevier Publisher's website
Journal:
European Journal of Pharmaceutical Sciences Journal website
Volume:
104
Pages:
382-392
Publication date:
2017-04-20
Acceptance date:
2017-04-17
DOI:
EISSN:
1879-0720
ISSN:
0928-0987
Pubs id:
pubs:908135
URN:
uri:10ab1b3d-d870-48ac-8b87-37886109801d
UUID:
uuid:10ab1b3d-d870-48ac-8b87-37886109801d
Local pid:
pubs:908135

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