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Hydrogen-bond-dependent conformational switching: a computational challenge from experimental thermochemistry

Abstract:

We have compiled an experimental data set (SWITCH10) of equilibrium constants for a series of hydrogen-bond-dependent conformational switches. These organic molecules possess common functionalities and are representative in terms of size and composition of systems routinely studied computationally. They exist as two well-defined conformations which serve as a useful tool to benchmark computational estimates of experimental Gibbs energy differences. We examine the performance of HF theory and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acs.joc.8b02436

Authors


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Role:
Author
ORCID:
0000-0002-1606-3917
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
St Hilda's College
Role:
Author
ORCID:
0000-0002-0104-4166
Publisher:
American Chemical Society
Journal:
Journal of Organic Chemistry More from this journal
Volume:
84
Issue:
2
Pages:
613–621
Publication date:
2018-12-26
Acceptance date:
2018-12-26
DOI:
EISSN:
1520-6904
ISSN:
0022-3263
Pmid:
30586500
Language:
English
Pubs id:
pubs:955270
UUID:
uuid:1022ff80-538d-4be6-b9f2-2b7e16ca65e3
Local pid:
pubs:955270
Source identifiers:
955270
Deposit date:
2019-02-11

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