Journal article
Association analyses identify 31 new risk loci for colorectal cancer susceptibility
- Abstract:
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Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gen...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.5MB, Terms of use)
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- Publisher copy:
- 10.1038/s41467-019-09775-w
Authors
Bibliographic Details
- Publisher:
- Springer Nature
- Journal:
- Nature Communications More from this journal
- Volume:
- 10
- Issue:
- 1
- Article number:
- 2154
- Publication date:
- 2019-05-14
- Acceptance date:
- 2019-03-29
- DOI:
- EISSN:
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2041-1723
- Pmid:
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31089142
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:998995
- UUID:
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uuid:10223632-1792-45cc-bd6b-01584b210022
- Local pid:
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pubs:998995
- Source identifiers:
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998995
- Deposit date:
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2019-05-29
Terms of use
- Copyright holder:
- Law et al
- Copyright date:
- 2019
- Notes:
- © The Authors. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
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