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MST2 kinase suppresses rDNA transcription in response to DNA damage by phosphorylating nucleolar histone H2B

Abstract:

The heavily transcribed rDNA repeats that give rise to the ribosomal RNA are clustered in a unique chromatin structure, the nucleolus. Due to its highly repetitive nature and transcriptional activity, the nucleolus is considered a hotspot of genomic instability. Breaks in rDNA induce a transient transcriptional shut down to conserve energy and promote rDNA repair; however, how nucleolar chromatin is modified and impacts on rDNA repair is unknown. Here, we uncover that phosphorylation of serin...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.15252/embj.201798760

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
ORCID:
0000-0002-1956-5111
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Oxford college:
Pembroke College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
ORCID:
0000-0002-0060-6278
Publisher:
EMBO Press Publisher's website
Journal:
EMBO journal Journal website
Volume:
37
Issue:
15
Publication date:
2018-05-22
Acceptance date:
2018-04-27
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Pubs id:
pubs:854119
URN:
uri:101c93d4-14f5-4701-8544-4fe8421da136
UUID:
uuid:101c93d4-14f5-4701-8544-4fe8421da136
Local pid:
pubs:854119
Language:
English
Keywords:

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